Anti-Human TrkA Reference Antibody (GBR 900, RUO) (HY107016)

Name: Anti-Human TrkA Reference Antibody (GBR 900, RUO)
Brand: abinScience
SKU: HY107016
Price: 326 USD
Availability: InStock

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Overview

Catalog No.	HY107016
Description	Anti-Human NTRK1/TRKA (GBR 900) (HY107016) is a research-grade recombinant antibody targeting Trk-A. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG
Clone ID	GBR 900
Expression system	Mammalian cells
Clonality	Monoclonal
Target	Trk-A, High affinity nerve growth factor receptor, NTRK1, Tropomyosin-related kinase A, Neurotrophic tyrosine kinase receptor type 1, MTC, TRKA, Tyrosine kinase receptor, TRK, p140-TrkA, TRK1-transforming tyrosine kinase protein, gp140trk, Tyrosine kinase receptor A
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P04629
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	GBR-900, GBR900, GBR900
Background	High affinity nerve growth factor receptor (NTRK1/TRKA) is a ~87 kDa protein. Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand. Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. 1. Jing, S. et al. (1992) Neuron 9, 1067-79. PMID: 1281417 2. Tacconelli, A. et al. (2004) Cancer cell 6, 347-60. PMID: 15488758 3. Wehrman, T. et al. (2007) Neuron 53, 25-38. PMID: 17196528 4. Klein, R. et al. (1991) Cell 65, 189-97. PMID: 1849459 5. Hempstead, BL. et al. (1991) Nature 350, 678-83. PMID: 1850821 6. Tong, Q. et al. (2012) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 26, 3811-21. PMID: 22649032 7. Anta, B. et al. (2016) The Journal of biological chemistry 291, 19132-45. PMID: 27445338 8. Barker, PA. et al. (1993) The Journal of biological chemistry 268, 15150-7. PMID: 8325889
Note	For research use only. Not suitable for clinical or therapeutic use.