Anti-Human TrkA Reference Antibody (GBR 900, RUO) (HY107016)

Name: Anti-Human TrkA Reference Antibody (GBR 900, RUO)
Brand: abinScience
SKU: HY107016
Price: 326 USD
Availability: InStock

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概要
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データシート
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概要

カタログ番号	HY107016
説明	Anti-Human NTRK1/TRKA (GBR 900) (HY107016) is a research-grade recombinant antibody targeting Trk-A. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
種反応性	Human
アプリケーション	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG
クローンID	GBR 900
発現システム	Mammalian cells
ターゲット	Trk-A, High affinity nerve growth factor receptor, NTRK1, Tropomyosin-related kinase A, Neurotrophic tyrosine kinase receptor type 1, MTC, TRKA, Tyrosine kinase receptor, TRK, p140-TrkA, TRK1-transforming tyrosine kinase protein, gp140trk, Tyrosine kinase receptor A
エンドトキシンレベル	< 10 EU/mg
純度	>95% purity as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	P04629
形態	Liquid
保存バッファー	0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	GBR-900, GBR900, GBR900
背景	High affinity nerve growth factor receptor (NTRK1/TRKA) is a ~87 kDa protein. Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand. Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. 1. Jing, S. et al. (1992) Neuron 9, 1067-79. PMID: 1281417 2. Tacconelli, A. et al. (2004) Cancer cell 6, 347-60. PMID: 15488758 3. Wehrman, T. et al. (2007) Neuron 53, 25-38. PMID: 17196528 4. Klein, R. et al. (1991) Cell 65, 189-97. PMID: 1849459 5. Hempstead, BL. et al. (1991) Nature 350, 678-83. PMID: 1850821 6. Tong, Q. et al. (2012) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 26, 3811-21. PMID: 22649032 7. Anta, B. et al. (2016) The Journal of biological chemistry 291, 19132-45. PMID: 27445338 8. Barker, PA. et al. (1993) The Journal of biological chemistry 268, 15150-7. PMID: 8325889
注意事項	For research use only. Not suitable for clinical or therapeutic use.