Anti-Human Siglec-8 Reference Antibody (AK001, RUO) (HP983066)

Name: Anti-Human Siglec-8 Reference Antibody (AK001, RUO)
Brand: abinScience
SKU: HP983066
Price: 326 USD
Availability: InStock

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Numéro de catalogue	HP983066
Description	Anti-Human SIGLEC8/SAF-2 (AK001) (HP983066) is a research-grade recombinant antibody targeting SAF2. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG
ID de clone	AK001
Système d'expression	Mammalian cells
Nature	Recombinant
Cible	SAF2, Sialoadhesin family member 2, SAF-2, Siglec-8, SIGLEC8, Sialic acid-binding Ig-like lectin 8
Niveau d'endotoxines	< 10 EU/mg as determined by LAL method.
Pureté	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	Q9NYZ4
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	AK001
Contexte	Sialic acid-binding Ig-like lectin 8 (SIGLEC8/SAF-2) is a ~54 kDa protein. Putative adhesion molecule that mediates sialic-acid dependent binding to blood cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Recognizes simultaneously epitopes having a terminal N-acetylneuraminic acid (sialic acid) and an underlying 6-O-sulfated galactose. 1. Floyd, H. et al. (2000) The Journal of biological chemistry 275, 861-6. PMID: 10625619 2. Kikly, KK. et al. (2000) The Journal of allergy and clinical immunology 105, 1093-100. PMID: 10856141 3. Pröpster, JM. et al. (2016) Proceedings of the National Academy of Sciences of the United States of America 113, E4170-9. PMID: 27357658
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Anti-Human SIGLEC8/SAF-2 (AK001)

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Anti-Human Siglec-8 Reference Antibody (AK001, RUO).pdf

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Anti-Human Siglec-8 Reference Antibody (AK001, RUO) (HP983066)

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SDS