Anti-Human VISTA/B7-H5/PD-1H Reference Antibody (HMBD-002, RUO) (HP543036)

Name: Anti-Human VISTA/B7-H5/PD-1H Reference Antibody (HMBD-002, RUO)
Brand: abinScience
SKU: HP543036
Price: 176 USD
Availability: InStock

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Каталожный номер	HP543036
Описание	Anti-Human VSIR/VISTA Antibody (HMBD-002) (HP543036) is a research-grade recombinant antibody targeting V-set domain-containing immunoregulatory receptor. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Реактивность видов	Human
Применения	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG4, kappa
ID клона	HMBD-002
Система экспрессии	Mammalian cells
Проверенные приложения	FCM
Цель	V-set domain-containing immunoregulatory receptor, C10orf54, VSIR, VISTA, SISP1, Stress-induced secreted protein-1, Platelet receptor Gi24, V-set immunoregulatory receptor, Sisp-1, V-type immunoglobulin domain-containing suppressor of T-cell activation
Уровень эндотоксинов	< 10 EU/mg
Чистота	>95% purity as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	Q9H7M9
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон	V-type immunoglobulin domain-containing suppressor of T-cell activation (VSIR/VISTA) is a ~33 kDa protein. Immunoregulatory receptor which inhibits the T-cell response. May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. May stimulate MMP14-mediated MMP2 activation. 1. Lines, JL. et al. (2014) Cancer research 74, 1924-32. PMID: 24691993 2. Sakr, MA. et al. (2010) Cancer science 101, 2368-74. PMID: 20666777
Примечание	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG4 (S228P & L235E) Recombinant Isotype Control Antibody (HyHEL-10) (HP614107)

Изображения

Bioactivity

Detects Human VSIR/VISTA in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Anti-Human VSIR/VISTA Antibody (HMBD-002).
Flow cytometry

Flow-cytometry APC using anti-human VSIR antibody. Untransfected cells (blue Histogram) and Transfected cells (Yellow Histogram) were stained with an APC anti-human VSIR monoclonal antibody (Catalog HP543036) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.
Flow cytometry

Flow-cytometry FITC using anti-human VSIR antibody. Untransfected cells (blue Histogram) and Transfected cells (Yellow Histogram) were stained with an FITC anti-human VSIR monoclonal antibody (Catalog HP543036) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.