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| カタログ番号 | JN856016 |
|---|---|
| 説明 |
Research Grade Bevifimod (JN856016) is a rabbit polyclonal antibody detecting Immunoglobulin G-binding protein A in Functional assay.
|
| アプリケーション | Functional assay |
| クローン性 | Monoclonal |
| 発現システム | Mammalian cells |
| 性質 | Recombinant |
| ターゲット | Immunoglobulin G-binding protein A, IgG-binding protein A, Staphylococcal protein A, SpA, spa |
| エンドトキシンレベル | < 10 EU/mg as determined by LAL method. |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | P38507 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | Immunoglobulin G-binding protein A is a ~55 kDa protein. Plays a role in the inhibition of the host innate and adaptive immune responses. Possesses five immunoglobulin-binding domains that capture both the fragment crystallizable region (Fc region) and the Fab region (part of Ig that identifies antigen) of immunoglobulins. In turn, Staphylococcus aureus is protected from phagocytic killing via inhibition of Ig Fc region. In addition, the host elicited B-cell response is prevented due to a decrease of antibody-secreting cell proliferation that enter the bone marrow, thereby decreasing long-term antibody production. Inhibits osteogenesis by preventing osteoblast proliferation and expression of alkaline phosphatase, type I collagen, osteopontin and osteocalcin. |
| 注意事項 | For research use only. Not suitable for clinical or therapeutic use. |
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