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| カタログ番号 | HB949016 |
|---|---|
| 説明 |
Bimagrumab (HB949016) is a research-grade recombinant antibody targeting ACVR2. Produced in mammalian cells with native-like glycosylation.
Highlights
|
| 種反応性 | Human |
| アプリケーション | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 宿主種 | Human |
| クローン性 | Monoclonal |
| アイソタイプ | IgG1-lambda |
| 発現システム | Mammalian cells |
| ターゲット | ACVR2, ACTRIIA, ACTR-IIA, Activin receptor type IIA, ACVR2A, Activin receptor type-2A, ACTR-IIB, Activin receptor type IIB, Activin receptor type-2B, ACVR2B |
| エンドトキシンレベル | < 10 EU/mg |
| 純度 | >95% purity as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | P27037 & Q13705 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | BYM338, 1356922-05-8 |
| 背景 | Bimagrumab is a monoclonal anti-ActRIIA/IIB antibody that targets ActRIIA and ActRIIB simultaneously. Native ActRIIA and ActRIIB are both mediators of signaling from several TGFβ superfamily members such as activins, myostatin, and GDF11. Hence, pan-blockade by Bimagrumab achieves greater effect than a monoclonal antibody against either receptor alone, i.e. monotherapy with anti-ActRIIA antibody or anti-ActRIIB antibody. Bimagrumab has been explored as a therapy for sporadic inclusion body myositis, primary sarcopenia, and muscle wasting associated with chronic obstructive pulmonary disease. • Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B., PMID:26047946 • BMPR2 inhibits activin and BMP signaling via wild-type ALK2., PMID:29739878 • ALK2/ALK3-BMPR2/ACVR2A Mediate BMP2-Induced Downregulation of Pentraxin 3 Expression in Human Granulosa-Lutein Cells., PMID:28977600 • Follicular localization of growth differentiation factor 8 and its receptors in normal and polycystic ovary syndrome ovaries., PMID:29409020 |
| 注意事項 | For research use only. Not suitable for clinical or therapeutic use. |
| Isotype Control | Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507) |
SEC-HPLC detection for Research Grade Bimagrumab.
Detects ACVR2A in indirect ELISAs.
Flow-cytometry using anti-human ACVR2A antibody. Hela cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human ACVR2A monoclonal antibody (Catalog HB949016, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a a Goat Anti-Human IgG H&L Polyclonal Antibody, FITC (abinScience: HF690414) and cells analysed on a NovoCyte Flow Cytometer.
SDS-PAGE for Research Grade Bimagrumab
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