Anti-Human Glycogen Reference Antibody (Clervonafusp Alfa, RUO) (HY377026)

Name: Anti-Human Glycogen Reference Antibody (Clervonafusp Alfa, RUO)
Brand: abinScience
SKU: HY377026
Price: 176 USD
Availability: InStock

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概要
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データシート
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概要

カタログ番号	HY377026
説明	Clervonafusp Alfa (HY377026) is a research-grade recombinant antibody targeting Equilibrative nitrobenzylmercaptopurine riboside-insensit.... Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
種反応性	Human
アプリケーション	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG1
発現システム	Mammalian cells
ターゲット	Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter, 36 kDa nucleolar protein HNP36, ENT2, Equilibrative nucleoside transporter 2, SLC29A2, Hydrophobic nucleolar protein, 36 kDa, Equilibrative NBMPR-insensitive nucleoside transporter, Nucleoside transporter, ei-type, Delayed-early response protein 12, Solute carrier family 29 member 2, HNP36, DER12
エンドトキシンレベル	< 10 EU/mg
純度	>95% purity as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	P10253
形態	Liquid
保存バッファー	0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	VAL-1221, 2145123-44-8
背景	Lysosomal alpha-glucosidase (ENT2/SLC29A2) is a ~105 kDa protein. Essential for the degradation of glycogen in lysosomes. Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans. 1. Hermans, MM. et al. (2004) Human mutation 23, 47-56. PMID: 14695532 2. Pittis, MG. et al. (2008) Human mutation 29, E27-36. PMID: 18429042 3. Hermans, MM. et al. (1991) The Journal of biological chemistry 266, 13507-12. PMID: 1856189 4. Boerkoel, CF. et al. (1995) American journal of human genetics 56, 887-97. PMID: 7717400 5. Roig-Zamboni, V. et al. (2017) Nature communications 8, 1111. PMID: 29061980
注意事項	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

イメージ

Flow Cytometry

Flow-cytometry using anti-human SLC29A2 antibody. HepG-2 cells were fixed and permeabilized, then stained with an irrelevant antibody (Blue Histogram) or an anti-human SLC29A2 monoclonal antibody (Catalog HY377026, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using Goat Anti-Human IgG H&L Polyclonal Antibody, FITC (abinScience: HF690414) and cells analysed on a NovoCyte Flow Cytometer.
Flow cytometry

Flow-cytometry using FITC anti-human SLC29A2 antibody. HepG2 cells were stained with an irrelevant antibody (Blue Histogram) or an FITC anti-human SLC29A2 monoclonal antibody (Catalog HY377026, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, and cells analysed on a NovoCyte Flow Cytometer.