Anti-Human ANGPTL4 Reference Antibody (Corveldebart, RUO) (HV344016)

Name: Anti-Human ANGPTL4 Reference Antibody (Corveldebart, RUO)
Brand: abinScience
SKU: HV344016
Price: 370 USD
Availability: InStock

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Especificación:

100ug
1mg
5mg
10mg
25mg
50mg
100mg

Número:

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Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HV344016

Descripción

Research Grade corveldebart (HV344016) is a human monoclonal antibody. Suitable for Human.

Reactividad de especies

Human

Aplicaciones

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Especie huésped

Human

Clonalidad

Monoclonal

Isotipo

IgG1, kappa

Nivel de endotoxinas

< 10 EU/mg

Pureza

>95% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

Q9BY76

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Angiopoietin-related protein 4 (ANGPTL4) is a ~45 kDa protein. Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity (Probable). Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro). Depending on context, may modulate tumor-related angiogenesis.

1. Yin, W. et al. (2009) The Journal of biological chemistry 284, 13213-22. PMID: 19270337

2. Lei, X. et al. (2011) The Journal of biological chemistry 286, 15747-56. PMID: 21398697

3. Mysling, S. et al. (2016) eLife 5. PMID: 27929370

4. Kristensen, KK. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, E6020-E6029. PMID: 29899144

5. Ito, Y. et al. (2003) Cancer research 63, 6651-7. PMID: 14583458

6. Cazes, A. et al. (2006) Circulation research 99, 1207-15. PMID: 17068295

Nota

For research use only.

Imágenes

Referencias

Datasheet