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| カタログ番号 | HV344016 | ||||
|---|---|---|---|---|---|
| 説明 |
Research Grade corveldebart (HV344016) is a human monoclonal antibody. Suitable for Human.
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| 種反応性 | Human | ||||
| アプリケーション | ELISA, Bioactivity: FACS, Functional assay, Research in vivo | ||||
| 宿主種 | Human | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG1, kappa | ||||
| エンドトキシンレベル | < 10 EU/mg | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q9BY76 | ||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 背景 | Angiopoietin-related protein 4 (ANGPTL4) is a ~45 kDa protein. Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity (Probable). Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro). Depending on context, may modulate tumor-related angiogenesis. 1. Yin, W. et al. (2009) The Journal of biological chemistry 284, 13213-22. PMID: 19270337 2. Lei, X. et al. (2011) The Journal of biological chemistry 286, 15747-56. PMID: 21398697 3. Mysling, S. et al. (2016) eLife 5. PMID: 27929370 4. Kristensen, KK. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, E6020-E6029. PMID: 29899144 5. Ito, Y. et al. (2003) Cancer research 63, 6651-7. PMID: 14583458 6. Cazes, A. et al. (2006) Circulation research 99, 1207-15. PMID: 17068295 | ||||
| 注意事項 | For research use only. |
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