

| Каталожный номер | HV344016 | ||||
|---|---|---|---|---|---|
| Описание |
Research Grade corveldebart (HV344016) is a human monoclonal antibody. Suitable for Human.
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| Реактивность видов | Human | ||||
| Применения | ELISA, Bioactivity: FACS, Functional assay, Research in vivo | ||||
| Хозяинский вид | Human | ||||
| Клоональность | Monoclonal | ||||
| Изотип | IgG1, kappa | ||||
| Уровень эндотоксинов | < 10 EU/mg | ||||
| Чистота | >95% as determined by SDS-PAGE. | ||||
| Очистка | Protein A/G purified from cell culture supernatant. | ||||
| Номер доступа | Q9BY76 | ||||
| Форма | Liquid | ||||
| Буфер хранения | 0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| Фон | Angiopoietin-related protein 4 (ANGPTL4) is a ~45 kDa protein. Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity (Probable). Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro). Depending on context, may modulate tumor-related angiogenesis. 1. Yin, W. et al. (2009) The Journal of biological chemistry 284, 13213-22. PMID: 19270337 2. Lei, X. et al. (2011) The Journal of biological chemistry 286, 15747-56. PMID: 21398697 3. Mysling, S. et al. (2016) eLife 5. PMID: 27929370 4. Kristensen, KK. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, E6020-E6029. PMID: 29899144 5. Ito, Y. et al. (2003) Cancer research 63, 6651-7. PMID: 14583458 6. Cazes, A. et al. (2006) Circulation research 99, 1207-15. PMID: 17068295 | ||||
| Примечание | For research use only. |




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