Anti-Human CD8 alpha Reference Antibody (Crefmirlimab, RUO) (HP158016)

Name: Anti-Human CD8 alpha Reference Antibody (Crefmirlimab, RUO)
Brand: abinScience
SKU: HP158016
Price: 176 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue	HP158016
Description	Crefmirlimab (HP158016) is a research-grade recombinant antibody targeting CD8. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	(scFv-kappa-heavy) -h- CH3
Système d'expression	Mammalian cells
Cible	T-cell surface glycoprotein CD8 alpha chain, CD8a, T-lymphocyte differentiation antigen T8/Leu-2, MAL, CD8A
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% purity as determined by SDS-PAGE.
Purification	Purified by ion exchange chromatography.
Numéro d'accès	P01732
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	89Zr-IAB22M2C, IAB22M2C, 89Zr-Df-IAB22M2C, 2611099-93-3
Contexte	T-cell surface glycoprotein CD8 alpha chain (CD8A) is a ~25 kDa protein. Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex.
Note	For research use only. Not suitable for clinical or therapeutic use.

Images

Bioactivity

Detects CD8A in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Crefmirlimab.

Reférences

Fiche technique

Anti-Human CD8 alpha Reference Antibody (Crefmirlimab, RUO).pdf

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Formula

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