Research Grade efmirenpase alfa (HB920016)

Name: Research Grade efmirenpase alfa
Brand: abinScience
SKU: HB920016
Price: 370 USD
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Número de catálogo	HB920016
Descripción	efmirenpase alfa (HB920016) is a research-grade recombinant antibody targeting ENPP1. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research.
Reactividad de especies	Human
Aplicaciones	Functional assay
Clonalidad	Monoclonal
Isotipo	ENPP1-Fc
Sistema de expresión	Mammalian cells
Naturaleza	Recombinant
Objetivo	ENPP1
Nivel de endotoxinas	< 10 EU/mg as determined by LAL method.
Pureza	>95% as determined by SDS-PAGE.
Número de acceso	P22413
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	CAS: 2770242-54-9
Fondo	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 is a ~104 kDa protein. Nucleotide pyrophosphatase that generates diphosphate (PPi) and functions in bone mineralization and soft tissue calcification by regulating pyrophosphate levels. PPi inhibits bone mineralization and soft tissue calcification by binding to nascent hydroxyapatite crystals, thereby preventing further growth of these crystals. Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP and UTP to their corresponding monophosphates with release of pyrophosphate, as well as diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling; it is however unclear whether hedgehog inhibition is direct or indirect. 1. Johnson, KA. et al. (2000) American journal of physiology. Regulatory, integrative and comparative physiology 279, R1365-77. PMID: 11004006 2. Li, L. et al. (2014) Nature chemical biology 10, 1043-8. PMID: 25344812 3. Stella, J. et al. (2016) Human mutation 37, 1190-1201. PMID: 27467858 4. Namasivayam, V. et al. (2017) Biochimica et biophysica acta. General subjects 1861, 603-614. PMID: 28011303 5. Szeri, F. et al. (2022) Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 37, 1024-1031. PMID: 35147247 6. Belli, SI. et al. (1994) European journal of biochemistry 226, 433-43. PMID: 8001561 7. Maddux, BA. et al. (2000) Diabetes 49, 13-9. PMID: 10615944 8. Chourabi, M. et al. (2018) The Journal of investigative dermatology 138, 291-300. PMID: 28964717
Nota	For research use only. Not suitable for clinical or therapeutic use.

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Research Grade efmirenpase alfa.pdf

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C₁ (Stock Conc.)

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Research Grade efmirenpase alfa (HB920016)

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