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| カタログ番号 | HB630036 |
|---|---|
| 説明 |
Research Grade Efprezimod alfa (HB630036) is a human monoclonal antibody detecting Signal transducer CD24 in FuncS. Suitable for Human.
|
| 種反応性 | Human |
| アプリケーション | FuncS |
| 宿主種 | Human |
| クローン性 | Monoclonal |
| アイソタイプ | Fusion - [CD24 (CD24 molecule, CD24 antigen (small cell lung carcinoma cluster 4 antigen))]2 - IGHG1 Fc |
| 発現システム | Mammalian cells |
| 性質 | Recombinant |
| ターゲット | Signal transducer CD24, Small cell lung carcinoma cluster 4 antigen, CD24, CD24, CD24A |
| エンドトキシンレベル | < 10 EU/mg as determined by LAL method. |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | P25063 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | Signal transducer CD24 (Siglec-10) is a ~8 kDa protein. May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. 1. Suzuki, T. et al. (2001) Journal of immunology (Baltimore, Md. : 1950) 166, 5567-77. PMID: 11313396 |
| 注意事項 | For research use only. Not suitable for clinical or therapeutic use. |
| Isotype Control | VHH-hFc (IgG1) Isotype Control antibody (cAb-Lys2) (ZP167307) |
SDS-PAGE for Research Grade Efprezimod alfa
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