Anti-Human Nectin-4 Reference Antibody (Enfortumab, RUO) (HV985016)

Name: Anti-Human Nectin-4 Reference Antibody (Enfortumab, RUO)
Brand: abinScience
SKU: HV985016
Price: 176 USD
Availability: InStock

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号	HV985016
説明	Enfortumab (HV985016) is a research-grade recombinant antibody targeting LNIR. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
種反応性	Human
アプリケーション	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG1-kappa
発現システム	Mammalian cells
テスト済みアプリケーション	WB, FCM
ターゲット	LNIR, NECTIN4, PRR4 receptor-related protein 4, Nectin cell adhesion molecule 4, Ig superfamily receptor LNIR, Nectin-4, PVRL4
エンドトキシンレベル	< 10 EU/mg
純度	>95% purity as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	Q96NY8
形態	Liquid
保存バッファー	0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	AGS-22CE, AGS-22M, AGS-22M6E, unconjugated:AGS-22C3orAGSM6, 1448664-46-7
背景	Nectin-4 (NECTIN4/PVRL4) is a ~55 kDa protein. Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells. NECTIN4 is the therapeutic target of enfortumab vedotin (Padcev).
注意事項	For research use only. Not suitable for clinical or therapeutic use.

イメージ

SEC-HPLC

SEC-HPLC detection for Research Grade Enfortumab.
Bioactivity

Detects NECTIN4/PVRL4 in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Enfortumab.
Flow CytoMetry

Flow-cytometry using anti-human Nectin 4 antibody. Untransfected cells (blue Histogram) and Transfected cells (Yellow Histogram) were stained with an anti-human Nectin 4 monoclonal antibody (Catalog: HV985016) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a Goat Anti-Human IgG H&L Polyclonal Antibody, FITC (abinScience: HF690414) and cells analysed on a NovoCyte Flow Cytometer.
Western blot

Western blot analysis was performed using anti-NECTIN4 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human NECTIN4 (Catalog No: HV985011)
Lane 2: negative control