中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HB771016 |
|---|---|
| 説明 |
Research Grade Enokizumab (HB771016) is a humanized monoclonal antibody detecting T-cell growth factor P40 in ELISA, Bioactivity: FACS, Functional assay, Research in vivo. Suitable for Human.
Highlights
|
| 種反応性 | Human |
| アプリケーション | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 宿主種 | Human |
| クローン性 | Monoclonal |
| アイソタイプ | IgG1-kappa |
| 発現システム | Mammalian cells |
| 種 | Human |
| ターゲット | T-cell growth factor P40, Cytokine P40, IL9, Interleukin-9, IL-9 |
| エンドトキシンレベル | < 10 EU/mg |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | P15248 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | 7F3com-2H2, MEDI-528, 909875-08-7 |
| 背景 | Interleukin-9 (T-cell growth factor P40,Cytokine P40,IL9,Interleukin-9,IL-9) is a ~15 kDa protein. Multifunctional cytokine secreted mainly by T-helper 2 lymphocytes and also mast cells or NKT cells that plays important roles in the immune response against parasites. Affects intestinal epithelial permeability and adaptive immunity. In addition, induces the differentiation of specific T-cell subsets such as IL-17 producing helper T-cells (TH17) and also proliferation and differentiation of mast cells. Mechanistically, exerts its biological effects through a receptor composed of IL9R subunit and a signal transducing subunit IL2RG. Receptor stimulation results in the rapid activation of JAK1 and JAK3 kinase activities leading to STAT1, STAT3 and STAT5-mediated transcriptional programs. 1. Renga, G. et al. (2018) Cell reports 23, 1767-1778. PMID: 29742432 |
| 注意事項 | For research use only. Not suitable for clinical or therapeutic use. |
| Isotype Control | Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507) |
SEC-HPLC detection for Research Grade Enokizumab.
SDS-PAGE for Research Grade Enokizumab.
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
