Anti-Human DLL4 Reference Antibody (Enoticumab, RUO) (HV571026)

Name: Anti-Human DLL4 Reference Antibody (Enoticumab, RUO)
Brand: abinScience
SKU: HV571026
Price: 176 USD
Availability: InStock

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Aperçu

Numéro de catalogue	HV571026
Description	Enoticumab (HV571026) is a research-grade recombinant antibody targeting Delta-like protein 4. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG1-kappa
Système d'expression	Mammalian cells
Applications testées	WB
Cible	Delta-like protein 4, Drosophila Delta homolog 4, Delta4, DLL4
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	Q9NR61
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	REGN-421, SAR153192, 1192578-27-0
Contexte	Delta-like protein 4 (DLL4) is a ~74 kDa protein. Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. 1. Yoneya, T. et al. (2001) Journal of biochemistry 129, 27-34. PMID: 11134954 2. Brütsch, R. et al. (2010) Circulation research 107, 592-601. PMID: 20616313 3. Del Barrio, MG. et al. (2007) Development (Cambridge, England) 134, 3427-36. PMID: 17728344
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Anti-LASV GPC Recombinant Antibody (Fab 37.7) (VK453013)

Images

SEC-HPLC

SEC-HPLC detection for Research Grade Enoticumab.
Bioactivity

Detects DLL4 in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Enoticumab.
Western blot

Western blot analysis was performed using anti-DLL4 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human DLL4 (Catalog No: HV571011)
Lane 2: negative control