Anti-Human DLL4 Reference Antibody (MEDI0639, RUO) (HV571056)

Name: Anti-Human DLL4 Reference Antibody (MEDI0639, RUO)
Brand: abinScience
SKU: HV571056
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HV571056
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG
Clone ID	MEDI0639
Biological activity	MEDI0639 promotes human angiogenesis and reduces the number of vessels covered by smooth muscle actin-positive mural cells. MEDI0639 can be used in Small cell lung cancer and solid tumors research [1].
Expression system	Mammalian cells
Clonality	Monoclonal
Target	Delta-like protein 4, Drosophila Delta homolog 4, Delta4, DLL4
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q9NR61
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	MEDI0639
Background	Delta-like protein 4 (DLL4) is a ~74 kDa protein. Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. 1. Yoneya, T. et al. (2001) Journal of biochemistry 129, 27-34. PMID: 11134954 2. Brütsch, R. et al. (2010) Circulation research 107, 592-601. PMID: 20616313 3. Del Barrio, MG. et al. (2007) Development (Cambridge, England) 134, 3427-36. PMID: 17728344
References	1. Jenkins DW, et al. MEDI0639: a novel therapeutic antibody targeting Dll4 modulates endothelial cell function and angiogenesis in vivo. Mol Cancer Ther. 2012 Aug;11(8):1650-60. [HV571056]
Note	For research use only. Not suitable for clinical or therapeutic use.