Anti-Human DLL4 Reference Antibody (Enoticumab, RUO) (HV571026)

Name: Anti-Human DLL4 Reference Antibody (Enoticumab, RUO)
Brand: abinScience
SKU: HV571026
Price: 176 USD
Availability: InStock

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100ug
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Изображения
Ссылки
Даташит
SDS

Обзор

Каталожный номер	HV571026
Описание	Enoticumab (HV571026) is a research-grade recombinant antibody targeting Delta-like protein 4. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Реактивность видов	Human
Применения	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG1-kappa
Система экспрессии	Mammalian cells
Проверенные приложения	WB
Цель	Delta-like protein 4, Drosophila Delta homolog 4, Delta4, DLL4
Уровень эндотоксинов	< 10 EU/mg
Чистота	>95% purity as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	Q9NR61
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	REGN-421, SAR153192, 1192578-27-0
Фон	Delta-like protein 4 (DLL4) is a ~74 kDa protein. Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. 1. Yoneya, T. et al. (2001) Journal of biochemistry 129, 27-34. PMID: 11134954 2. Brütsch, R. et al. (2010) Circulation research 107, 592-601. PMID: 20616313 3. Del Barrio, MG. et al. (2007) Development (Cambridge, England) 134, 3427-36. PMID: 17728344
Примечание	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Anti-LASV GPC Recombinant Antibody (Fab 37.7) (VK453013)

Изображения

SEC-HPLC

SEC-HPLC detection for Research Grade Enoticumab.
Bioactivity

Detects DLL4 in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Enoticumab.
Western blot

Western blot analysis was performed using anti-DLL4 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human DLL4 (Catalog No: HV571011)
Lane 2: negative control