Anti-Human IL-22 Reference Antibody (Fezakinumab, RUO) (HV999016)

Name: Anti-Human IL-22 Reference Antibody (Fezakinumab, RUO)
Brand: abinScience
SKU: HV999016
Price: 176 USD
Availability: InStock

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100ug
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Даташит
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Обзор

Каталожный номер	HV999016
Описание	Research Grade Fezakinumab (HV999016) is a human monoclonal antibody detecting Interleukin-22 in ELISA, Bioactivity: FACS, Functional assay, Research in vivo. Suitable for Human. Highlights ●Multi-Application — Validated across multiple applications.
Реактивность видов	Human
Применения	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG1-lambda
Система экспрессии	Mammalian cells
Виды	Human
Цель	Interleukin-22, Cytokine Zcyto18, IL-22, ZCYTO18, IL22, ILTIF, IL-TIF, IL-10-related T-cell-derived-inducible factor
Уровень эндотоксинов	< 10 EU/mg
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	Q9GZX6
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	ILV-094, 1007106-86-6
Фон	Interleukin-22 (Interleukin-22,Cytokine Zcyto18,IL-22,ZCYTO18,IL22,ILTIF,IL-TIF,IL-10-related T-cell-derived-inducible factor) is a ~20 kDa protein. Cytokine that plays a critical role in modulating tissue responses during inflammation. Plays an essential role in the regeneration of epithelial cells to maintain barrier function after injury and for the prevention of further tissue damage. Unlike most of the cytokines, has no effect on immune cells. Signals through a heterodimeric receptor composed of two subunits, the specific receptor IL22RA1 which is present on non-immune cells in many organs and the shared subunit IL10RB. Ligation of IL22RA1 with IL22 induces activation of the tyrosine kinases JAK1 and TYK2, which in turn activates STAT3. 1. Brand, S. et al. (2007) American journal of physiology. Gastrointestinal and liver physiology 292, G1019-28. PMID: 17204547 2. Xie, MH. et al. (2000) The Journal of biological chemistry 275, 31335-9. PMID: 10875937 3. Jones, BC. et al. (2008) Structure (London, England : 1993) 16, 1333-44. PMID: 18599299 4. Akil, H. et al. (2015) PloS one 10, e0119872. PMID: 25793261 5. Moniruzzaman, M. et al. (2019) International journal of molecular sciences 20. PMID: 31311100
Примечание	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1, lambda Isotype Control antibody (HyHEL-10) (HP248107)

Изображения

Bioactivity

SEC-HPLC detection for Research Grade Fezakinumab.
SDS-PAGE

SDS-PAGE for Research Grade Fezakinumab.

Ссылки

Даташит

Anti-Human IL-22 Reference Antibody (Fezakinumab, RUO).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Working Solution

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