Anti-Human TYRP1 Reference Antibody (Flanvotumab, RUO) (HB884016)

Name: Anti-Human TYRP1 Reference Antibody (Flanvotumab, RUO)
Brand: abinScience
SKU: HB884016
Price: 176 USD
Availability: InStock

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Обзор

Каталожный номер	HB884016
Описание	Flanvotumab (HB884016) is a research-grade recombinant antibody targeting 5. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Реактивность видов	Human
Применения	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG1-kappa
Система экспрессии	Mammalian cells
Цель	5, 6-dihydroxyindole-2-carboxylic acid oxidase, Glycoprotein 75, CAS2, TYRP1, TRP-1, TYRRP, TRP1, Catalase B, TYRP, Melanoma antigen gp75, TRP, DHICA oxidase, Tyrosinase-related protein 1
Уровень эндотоксинов	< 10 EU/mg
Чистота	>95% purity as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P17643
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	20D7S, IMC-20D7S, 1188277-05-5
Фон	5,6-dihydroxyindole-2-carboxylic acid oxidase (TYRP1) is a ~60 kDa protein. Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+). May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin. 1. Rooryck, C. et al. (2006) Pigment cell research 19, 239-42. PMID: 16704458 2. Kenny, EE. et al. (2012) Science (New York, N.Y.) 336, 554. PMID: 22556244 3. Simeonov, DR. et al. (2013) Human mutation 34, 827-35. PMID: 23504663 4. Lai, X. et al. (2017) Angewandte Chemie (International ed. in English) 56, 9812-9815. PMID: 28661582
Примечание	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (HyHEL-10) (HV080407) Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

Изображения

Bioactivity

SEC-HPLC detection for Research Grade Flanvotumab.
SDS-PAGE

SDS-PAGE for Anti-Human TYRP1 Reference Antibody (Flanvotumab, RUO)

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Даташит

Anti-Human TYRP1 Reference Antibody (Flanvotumab, RUO).pdf

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