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| カタログ番号 | HV989016 |
|---|---|
| 説明 |
Research Grade Fletikumab (HV989016) is a human monoclonal antibody detecting IL20 in ELISA, Bioactivity: FACS, Functional assay, Research in vivo. Suitable for Human.
Highlights
|
| 種反応性 | Human |
| アプリケーション | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 宿主種 | Human |
| クローン性 | Monoclonal |
| アイソタイプ | IgG4-kappa |
| 発現システム | Mammalian cells |
| 種 | Human |
| ターゲット | IL20, Cytokine Zcyto10, ZCYTO10, IL-20, Interleukin-20 |
| エンドトキシンレベル | < 10 EU/mg |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | Q9NYY1 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | 15D2, NN-8226, NNC-0109-0012, 1357158-22-5 |
| 背景 | Interleukin-20 (IL20,Cytokine Zcyto10,ZCYTO10,IL-20,Interleukin-20) is a ~20 kDa protein. Pro-inflammatory and angiogenic cytokine mainly secreted by monocytes and skin keratinocytes that plays crucial roles in immune responses, regulation of inflammatory responses, hemopoiesis, as well as epidermal cell and keratinocyte differentiation. Enhances tissue remodeling and wound-healing activities and restores the homeostasis of epithelial layers during infection and inflammatory responses to maintain tissue integrity. Affects multiple actin-mediated functions in activated neutrophils leading to inhibition of phagocytosis, granule exocytosis, and migration. Exert its effects via the type I IL-20 receptor complex consisting of IL20RA and IL20RB. Alternatively, can mediate its activity through a second receptor complex called type II IL-20 receptor complex composed of IL22RA1 and IL20RB. 1. Sa, SM. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 178, 2229-40. PMID: 17277128 2. Hsu, YH. et al. (2021) Immunology 164, 817-833. PMID: 34403503 3. Gough, P. et al. (2017) Journal of immunology (Baltimore, Md. : 1950) 198, 4373-4382. PMID: 28424238 4. Wang, M. et al. (2002) The Journal of biological chemistry 277, 7341-7. PMID: 11706020 5. Dumoutier, L. et al. (2001) Journal of immunology (Baltimore, Md. : 1950) 167, 3545-9. PMID: 11564763 6. Andrés, RM. et al. (2013) Experimental dermatology 22, 323-8. PMID: 23614738 |
| 注意事項 | For research use only. Not suitable for clinical or therapeutic use. |
| Isotype Control | Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4) (HP298207) |
SEC-HPLC detection for Research Grade Fletikumab.
SDS-PAGE for Research Grade Fletikumab.
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