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Anti-Human IL20 Recombinant Antibody (SAA0389), FITC (HV989117)

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Overview
Catalog No.HV989117
Species reactivityHuman
ApplicationsELISA, FCM
Host speciesMouse
IsotypeIgG1, kappa
Clone IDSAA0389
ConjugationFITC
Clonality Monoclonal
Target IL20, Cytokine Zcyto10, ZCYTO10, IL-20, Interleukin-20
Endotoxin level Please contact with the lab for this information.
Associated products Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), FITC
Accession Q9NYY1
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Stability and Storage Store at 4°C for 12 months. Protect from light. Do not freeze.
Background

Interleukin-20 (IL20) is a ~20 kDa protein. Pro-inflammatory and angiogenic cytokine mainly secreted by monocytes and skin keratinocytes that plays crucial roles in immune responses, regulation of inflammatory responses, hemopoiesis, as well as epidermal cell and keratinocyte differentiation. Enhances tissue remodeling and wound-healing activities and restores the homeostasis of epithelial layers during infection and inflammatory responses to maintain tissue integrity. Affects multiple actin-mediated functions in activated neutrophils leading to inhibition of phagocytosis, granule exocytosis, and migration. Exert its effects via the type I IL-20 receptor complex consisting of IL20RA and IL20RB. Alternatively, can mediate its activity through a second receptor complex called type II IL-20 receptor complex composed of IL22RA1 and IL20RB.

1. Sa, SM. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 178, 2229-40. PMID: 17277128
2. Hsu, YH. et al. (2021) Immunology 164, 817-833. PMID: 34403503
3. Gough, P. et al. (2017) Journal of immunology (Baltimore, Md. : 1950) 198, 4373-4382. PMID: 28424238
4. Wang, M. et al. (2002) The Journal of biological chemistry 277, 7341-7. PMID: 11706020
5. Dumoutier, L. et al. (2001) Journal of immunology (Baltimore, Md. : 1950) 167, 3545-9. PMID: 11564763
6. Andrés, RM. et al. (2013) Experimental dermatology 22, 323-8. PMID: 23614738
Note For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.
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Formula
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