Anti-Human IL-20 Reference Antibody (Fletikumab, RUO) (HV989016)

Name: Anti-Human IL-20 Reference Antibody (Fletikumab, RUO)
Brand: abinScience
SKU: HV989016
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HV989016
Description	Research Grade Fletikumab (HV989016) is a human monoclonal antibody detecting IL20 in ELISA, Bioactivity: FACS, Functional assay, Research in vivo. Suitable for Human. Highlights ●Multi-Application — Validated across multiple applications.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG4-kappa
Expression system	Mammalian cells
Species	Human
Clonality	Monoclonal
Target	IL20, Cytokine Zcyto10, ZCYTO10, IL-20, Interleukin-20
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q9NYY1
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	15D2, NN-8226, NNC-0109-0012, 1357158-22-5
Background	Interleukin-20 (IL20,Cytokine Zcyto10,ZCYTO10,IL-20,Interleukin-20) is a ~20 kDa protein. Pro-inflammatory and angiogenic cytokine mainly secreted by monocytes and skin keratinocytes that plays crucial roles in immune responses, regulation of inflammatory responses, hemopoiesis, as well as epidermal cell and keratinocyte differentiation. Enhances tissue remodeling and wound-healing activities and restores the homeostasis of epithelial layers during infection and inflammatory responses to maintain tissue integrity. Affects multiple actin-mediated functions in activated neutrophils leading to inhibition of phagocytosis, granule exocytosis, and migration. Exert its effects via the type I IL-20 receptor complex consisting of IL20RA and IL20RB. Alternatively, can mediate its activity through a second receptor complex called type II IL-20 receptor complex composed of IL22RA1 and IL20RB. 1. Sa, SM. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 178, 2229-40. PMID: 17277128 2. Hsu, YH. et al. (2021) Immunology 164, 817-833. PMID: 34403503 3. Gough, P. et al. (2017) Journal of immunology (Baltimore, Md. : 1950) 198, 4373-4382. PMID: 28424238 4. Wang, M. et al. (2002) The Journal of biological chemistry 277, 7341-7. PMID: 11706020 5. Dumoutier, L. et al. (2001) Journal of immunology (Baltimore, Md. : 1950) 167, 3545-9. PMID: 11564763 6. Andrés, RM. et al. (2013) Experimental dermatology 22, 323-8. PMID: 23614738
Note	For research use only. Not suitable for clinical or therapeutic use.

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Bioactivity

SEC-HPLC detection for Research Grade Fletikumab.
SDS-PAGE

SDS-PAGE for Research Grade Fletikumab.

References

Datasheet

Anti-Human IL-20 Reference Antibody (Fletikumab, RUO).pdf

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Anti-Human IL-20 Reference Antibody (Fletikumab, RUO) (HV989016)

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