Anti-Human Coagulation Factor XII Reference Antibody (Garadacimab, RUO) (HF664016)

Name: Anti-Human Coagulation Factor XII Reference Antibody (Garadacimab, RUO)
Brand: abinScience
SKU: HF664016
Price: 176 USD
Availability: InStock

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Aperçu

Numéro de catalogue	HF664016
Description	Garadacimab (HF664016) is a research-grade recombinant antibody targeting F12. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG4-lambda
Système d'expression	Mammalian cells
Cible	F12, HAF, Hageman factor, Beta-factor XIIa part 2, Coagulation factor XII
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P00748
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	CSL312, 2162134-62-3
Contexte	Coagulation factor XII (F12/Coagulationfactor XII) is a ~67 kDa protein. Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. 1. Naito, K. et al. (1991) The Journal of biological chemistry 266, 7353-8. PMID: 2019570 2. MacQuarrie, JL. et al. (2011) Blood 117, 4134-41. PMID: 21304106 3. Brunnée, T. et al. (1993) Blood 81, 580-6. PMID: 8427954
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG4 (S228P) Recombinant Isotype Control Antibody (SAA0184) (HP298107)

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Bioactivity

SEC-HPLC detection for Research Grade Garadacimab.
SDS-PAGE

SDS-PAGE for Research Grade Garadacimab

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Fiche technique

Anti-Human Coagulation Factor XII Reference Antibody (Garadacimab, RUO).pdf

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