Anti-Human Coagulation Factor XII Reference Antibody (Garadacimab, RUO) (HF664016)

Name: Anti-Human Coagulation Factor XII Reference Antibody (Garadacimab, RUO)
Brand: abinScience
SKU: HF664016
Price: 176 USD
Availability: InStock

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100ug
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Обзор

Каталожный номер	HF664016
Описание	Garadacimab (HF664016) is a research-grade recombinant antibody targeting F12. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Реактивность видов	Human
Применения	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG4-lambda
Система экспрессии	Mammalian cells
Цель	F12, HAF, Hageman factor, Beta-factor XIIa part 2, Coagulation factor XII
Уровень эндотоксинов	< 10 EU/mg
Чистота	>95% purity as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P00748
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	CSL312, 2162134-62-3
Фон	Coagulation factor XII (F12/Coagulationfactor XII) is a ~67 kDa protein. Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. 1. Naito, K. et al. (1991) The Journal of biological chemistry 266, 7353-8. PMID: 2019570 2. MacQuarrie, JL. et al. (2011) Blood 117, 4134-41. PMID: 21304106 3. Brunnée, T. et al. (1993) Blood 81, 580-6. PMID: 8427954
Примечание	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG4 (S228P) Recombinant Isotype Control Antibody (SAA0184) (HP298107)

Изображения

Bioactivity

SEC-HPLC detection for Research Grade Garadacimab.
SDS-PAGE

SDS-PAGE for Research Grade Garadacimab

Ссылки

Даташит

Anti-Human Coagulation Factor XII Reference Antibody (Garadacimab, RUO).pdf

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Formula

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