Anti-Human EphA3 Reference Antibody (Ifabotuzumab, RUO) (HB681016)

Name: Anti-Human EphA3 Reference Antibody (Ifabotuzumab, RUO)
Brand: abinScience
SKU: HB681016
Price: 176 USD
Availability: InStock

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100ug
1mg
5mg
10mg
25mg
50mg
100mg

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Vista general

Número de catálogo	HB681016
Descripción	Ifabotuzumab (HB681016) is a research-grade recombinant antibody targeting HEK. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG1-kappa
Sistema de expresión	Mammalian cells
Objetivo	HEK, Eph-like tyrosine kinase 1, EK4, EPHA3, Tyrosine-protein kinase receptor ETK1, Tyrosine-protein kinase TYRO4, Ephrin type-A receptor 3, hEK4, ETK, TYRO4, ETK1, Human embryo kinase, EPH-like kinase 4
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% purity as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P29320
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	Fibatuzumab, KB-004, 1234137-51-9
Fondo	Ephrin type-A receptor 3 (EPHA3) is a ~110 kDa protein. Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Also activated by EFNA1, inhibiting epithelial-to-mesenchymal transition of cardiac cells and playing a role in heart development. 1. Lawrenson, ID. et al. (2002) Journal of cell science 115, 1059-72. PMID: 11870224 2. Sharfe, N. et al. (2003) Journal of immunology (Baltimore, Md. : 1950) 170, 6024-32. PMID: 12794130
Nota	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

Imágenes

SEC-HPLC

SEC-HPLC detection for Research Grade Ifabotuzumab.
Bioactivity

Detects EPHA3 in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Ifabotuzumab.
Flow Cytometry

Flow-cytometry using anti-human EPHA3 antibody. Jurkat cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human EPHA3 monoclonal antibody (Catalog HB681016, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a a Goat Anti-Human IgG H&L Polyclonal Antibody, FITC (abinScience: HF690414) and cells analysed on a NovoCyte Flow Cytometer.