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| カタログ番号 | HF990026 |
|---|---|
| 種反応性 | Human |
| アプリケーション | ELISA, Functional assay, Research in vivo |
| アイソタイプ | Recombinant human Insulin analogue |
| 生物学的活性 | Insulin cattle is the two-chain polypeptide hormone produced by the β-cells of pancreatic islets. The α and β chains are joined by two interchain disulfide bonds. The α chain contains an intrachain disulfide bond. Insulin regulates glucose uptake into muscle and fat cells by recruiting membrane glucose transporter Glut-4 to cell surface. Insulin cattle has often been used as growth supplement in culturing cells at the concentration ranging from 1 to 10 ug/mL of medium [1]. in the pancreatic β cells. Insulin cattle has often been used as growth supplement in culturing cells. |
| 発現システム | Mammalian cells |
| ターゲット | INS, Insulin |
| エンドトキシンレベル | < 10 EU/mg |
| 純度 | >95% purity as determined by SDS-PAGE. |
| 精製 | Purified by Nickel column. |
| アクセッション番号 | P01308 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | Insulin is a ~11 kDa protein. Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. |
| 参考文献 | 1. Yousefi R, et al. Aspirin-mediated acetylation induces structural alteration and aggregation of bovine pancreaticinsulin. J Biomol Struct Dyn. 2016;34(2):362-75. [HF990026] |
| 注意事項 | For research use only. Not suitable for clinical or therapeutic use. |
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