Anti-Human IL-3R alpha Reference Antibody (Lixarkitug, RUO) (HX913036)

Name: Anti-Human IL-3R alpha Reference Antibody (Lixarkitug, RUO)
Brand: abinScience
SKU: HX913036
Price: 176 USD
Availability: InStock

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Numéro de catalogue	HX913036
Description	lixarkitug (HX913036) is a research-grade recombinant antibody targeting CD123. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research.
Reactivité des espèces	Human
Applications	ELISA, FACS, Functional assay
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG1, kappa
Cible	CD123, IL-3 receptor subunit alpha, IL-3R subunit alpha, IL-3R-alpha, IL-3RA, IL3R, IL3RA, Interleukin-3 receptor subunit alpha
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% as determined by SDS-PAGE
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P26951
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	CAS: 3035710-69-8
Contexte	Interleukin-3 receptor subunit alpha (IL3RA) is a ~43 kDa protein. Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program. 1. Huang, S. et al. (1999) Stem cells (Dayton, Ohio) 17, 265-72. PMID: 10527461
Note	For research use only.