Research Grade Mirostipen (HB896016)

Name: Research Grade Mirostipen
Brand: abinScience
SKU: HB896016
Price: 424 USD
Availability: InStock

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Aperçu

Numéro de catalogue	HB896016
Description	Mirostipen (HB896016) is a research-grade recombinant antibody targeting CD191. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactivité des espèces	Human
Applications	ELISA, Functional assay, Research in vivo
Clonalité	Monoclonal
Isotype	CCL23 protein
Système d'expression	Mammalian cells
Cible	CMKR1, SCYAR1, Macrophage inflammatory protein 1-alpha receptor, CMKBR1, MIP-1alpha-R, HM145, CC-CKR-1, RANTES-R, LD78 receptor, CCR-1, C-C chemokine receptor type 1, CCR1, CD191, C-C CKR-1
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P32246
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	HG00300, HG-00300, HGO0300, HGO-0300, Mirostipen(USAN/INN), MPIF1
Contexte	C-C chemokine receptor type 1 (CD191/CCR1) is a ~41 kDa protein. Chemokine receptor that plays a crucial role in regulating immune cell migration, inflammation, and immune responses. Contributes to the inflammatory response by recruiting immune cells, such as monocytes, macrophages, T-cells, and dendritic cells, to sites of inflammation for the clearance of pathogens and the resolution of tissue damage. When activated by its ligands including CCL3, CCL5-9, CCL13-16 and CCL23, triggers a signaling cascade within immune cells, leading to their migration towards the source of the chemokine. For example, mediates neutrophil migration after activation by CCL3 leading to the sequential release of TNF and leukotriene B4. Also mediates monocyte migration upon CXCL4 binding. 1. Tian, Y. et al. (2004) European journal of immunology 34, 785-795. PMID: 14991608 2. Berahovich, RD. et al. (2005) Journal of immunology (Baltimore, Md. : 1950) 174, 7341-51. PMID: 15905581 3. Wei, H. et al. (2024) Cellular signalling 117, 111122. PMID: 38417634 4. Fox, JM. et al. (2018) Scientific reports 8, 9466. PMID: 29930254
Note	For research use only. Not suitable for clinical or therapeutic use.

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Research Grade Mirostipen.pdf

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