Anti-Human IL-1 RAcP/IL-1 R3 Reference Antibody (Nadunolimab, RUO) (HV556016)

Name: Anti-Human IL-1 RAcP/IL-1 R3 Reference Antibody (Nadunolimab, RUO)
Brand: abinScience
SKU: HV556016
Price: 176 USD
Availability: InStock

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Numéro de catalogue	HV556016
Description	Nadunolimab (HV556016) is a research-grade recombinant antibody targeting IL-1R3. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG1-kappa
Système d'expression	Mammalian cells
Cible	IL-1R3, C3orf13, Interleukin-1 receptor 3, Interleukin-1 receptor accessory protein, IL1RAP, IL-1R-3, IL-1 receptor accessory protein, IL1R3, IL-1RAcP
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	Q9NPH3
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	CAN-04, CAN04, Nidanilimab, 2171061-85-9
Contexte	Interleukin-1 receptor accessory protein (IL1RAP) is a ~65 kDa protein. Coreceptor for IL1RL2 in the IL-36 signaling system. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex.
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)