Anti-Human LINGO1 Reference Antibody (Opicinumab, RUO) (HV367016)

Name: Anti-Human LINGO1 Reference Antibody (Opicinumab, RUO)
Brand: abinScience
SKU: HV367016
Price: 176 USD
Availability: InStock

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Спецификация:

100ug
1mg
5mg
10mg
25mg
50mg
100mg

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Обзор
Изображения
Ссылки
Даташит
SDS

Обзор

Каталожный номер	HV367016
Описание	Opicinumab (HV367016) is a research-grade recombinant antibody targeting LRRN6A. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Реактивность видов	Human
Применения	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG1-kappa
Система экспрессии	Mammalian cells
Цель	LRRN6A, LERN1, Leucine-rich repeat neuronal protein 1, Leucine-rich repeat and immunoglobulin domain-containing protein 1, LINGO1, Leucine-rich repeat neuronal protein 6A, Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Уровень эндотоксинов	< 10 EU/mg
Чистота	>95% purity as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	Q96FE5
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	BIIB-033, 1422268-07-2
Фон	Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (LINGO1) is a ~69 kDa protein. Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development. 1. Mi, S. et al. (2004) Nature neuroscience 7, 221-8. PMID: 14966521 2. Park, JB. et al. (2005) Neuron 45, 345-51. PMID: 15694321 3. Mi, S. et al. (2005) Nature neuroscience 8, 745-51. PMID: 15895088
Примечание	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

Изображения

Bioactivity

SEC-HPLC detection for Research Grade Opicinumab.
SDS-PAGE

SDS-PAGE for Research Grade Opicinumab.

Ссылки

Даташит

Anti-Human LINGO1 Reference Antibody (Opicinumab, RUO).pdf

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Formula

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