Anti-Human beta-NGF Reference Antibody (Povovetug, RUO) (HF909116)

Name: Anti-Human beta-NGF Reference Antibody (Povovetug, RUO)
Brand: abinScience
SKU: HF909116
Price: 176 USD
Availability: InStock

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100ug
1mg
5mg
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50mg
100mg

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SDS

Aperçu

Numéro de catalogue

HF909116

Description

povovetug (HF909116) is a research-grade recombinant antibody targeting NGF/Beta-NGF.

Highlights

●Research Grade — For PK/PD studies, assay development, and ADA research.

Reactivité des espèces

Feline

Applications

ELISA, FCM, Functional assay

Espèce hôte

Feline

Clonalité

Monoclonal

Isotype

IgG1, kappa

Cible

Beta-NGF, Beta-nerve growth factor, NGF, NGFB

Niveau d'endotoxines

< 10 EU/mg

Pureté

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

P01138

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Noms alternatifs

CAS: 2975573-74-9

Contexte

Beta-nerve growth factor is a ~26 kDa protein. Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (Probable). The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI.

1. Einarsdottir, E. et al. (2004) Human molecular genetics 13, 799-805. PMID: 14976160

2. Carvalho, OP. et al. (2011) Journal of medical genetics 48, 131-5. PMID: 20978020

3. Wijeyewickrema, LC. et al. (2010) The Journal of biological chemistry 285, 11793-9. PMID: 20164177

Note

For research use only.

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