Anti-Human alpha-Synuclein Reference Antibody (Prasinezumab, RUO) (HW755026)

Name: Anti-Human alpha-Synuclein Reference Antibody (Prasinezumab, RUO)
Brand: abinScience
SKU: HW755026
Price: 176 USD
Availability: InStock

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Aperçu

Numéro de catalogue	HW755026
Description	Prasinezumab (HW755026) is a research-grade recombinant antibody targeting Alpha-synuclein. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG1-kappa
Système d'expression	Mammalian cells
Applications testées	WB
Cible	Alpha-synuclein, PARK1, Non-A4 component of amyloid precursor, NACP, Non-A beta component of AD amyloid, SNCA
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P37840
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	PRX002, RG-7935, 1960462-19-4
Contexte	Alpha-synuclein (SNCA) is a ~14 kDa protein. Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. 1. Burré, J. et al. (2010) Science (New York, N.Y.) 329, 1663-7. PMID: 20798282 2. Butler, B. et al. (2015) The Journal of biological chemistry 290, 29542-54. PMID: 26442590 3. Logan, T. et al. (2017) Nature neuroscience 20, 681-689. PMID: 28288128 4. Huang, CC. et al. (2018) Journal of cell science 131. PMID: 30404828
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (HyHEL-10) (HV080407) Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

Images

SDS-PAGE

SDS-PAGE for Anti-Human alpha-Synuclein Reference Antibody (Prasinezumab, RUO)
SEC-HPLC

SEC-HPLC detection for Research Grade Prasinezumab.
Bioactivity

Detects SNCA in indirect ELISAs.
Western blot

Western blot analysis was performed using anti-SNCA monoclonal antibody at 1μg/ml on various samples.
Lane 1: recombinant human SNCA (Catalog No: HW755012), 50ng
Lane 2: recombinant human SNCA (Catalog No: HW755012), 30ng
Lane 3: recombinant human SNCA (Catalog No: HW755012), 20ng
Lane 4: recombinant human SNCA (Catalog No: HW755012), 10ng