Anti-Bacillus anthracis pagA/Protective antigen/PAD4 Reference Antibody (Raxibacumab, RUO) (JN898026)

Name: Anti-Bacillus anthracis pagA/Protective antigen/PAD4 Reference Antibody (Raxibacumab, RUO)
Brand: abinScience
SKU: JN898026
Price: 176 USD
Availability: InStock

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概要
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概要

カタログ番号	JN898026
説明	Raxibacumab (JN898026) is a research-grade recombinant antibody targeting Protective antigen. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
種反応性	Bacillus anthracis
アプリケーション	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG1-lambda
発現システム	Mammalian cells
ターゲット	Protective antigen, PA, Anthrax toxins translocating protein, PA-83, PA83, Protective antigen PA-20, PA-20, PA20, Protective antigen PA-63, PA-63, PA63, pagA, pag, pXO1-110, BXA0164, GBAA_pXO1_0164
エンドトキシンレベル	< 10 EU/mg
純度	>95% purity as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	P13423
形態	Liquid
保存バッファー	0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	565451-13-0
背景	Protective antigen (PA/pagA) is a ~85 kDa protein. Protective antigen constitutes one of the three proteins composing the anthrax toxin; it mediates attachment to host cells and translocation of edema factor (EF) and lethal factor (LF) into the host cytoplasm. PA associated with LF forms the lethal toxin (LeTx) and causes death when injected; PA associated with EF forms the edema toxin (EdTx) and produces edema. PA induces immunity to infection with anthrax. 1. Bradley, KA. et al. (2001) Nature 414, 225-9. PMID: 11700562 2. Bradley, KA. et al. (2003) The Journal of biological chemistry 278, 49342-7. PMID: 14507921 3. Santelli, E. et al. (2004) Nature 430, 905-8. PMID: 15243628 4. Lacy, DB. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 13147-51. PMID: 15326297 5. Singh, Y. et al. (1991) The Journal of biological chemistry 266, 15493-7. PMID: 1651334 6. Mock, M. et al. (2001) Annual review of microbiology 55, 647-71. PMID: 11544370
注意事項	For research use only. Not suitable for clinical or therapeutic use.