Anti-Human GDF15/MIC1 Reference Antibody (Rilogrotug, RUO) (HV986046)

Name: Anti-Human GDF15/MIC1 Reference Antibody (Rilogrotug, RUO)
Brand: abinScience
SKU: HV986046
Price: 176 USD
Availability: InStock

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100ug
1mg
5mg
10mg
25mg
50mg
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概要
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概要

カタログ番号	HV986046
説明	rilogrotug (HV986046) is a research-grade recombinant antibody targeting GDF15/MIC1. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research.
種反応性	Human
アプリケーション	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG1, Kappa
種	Human
ターゲット	GDF15/MIC1
エンドトキシンレベル	< 10 EU/mg
純度	>95% as determined by SDS-PAGE.
アクセッション番号	Q99988
形態	Liquid
再構成	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
発送	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	2894138-72-6
背景	Growth/differentiation factor 15 (GDF15/MIC1) is a ~34 kDa protein. Hormone produced in response to various stresses to confer information about those stresses to the brain, and trigger an aversive response, characterized by nausea, vomiting, and/or loss of appetite. The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future. Acts by binding to its receptor, GFRAL, activating GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes responses to stressful conditions. The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues. 1. Tsai, VW. et al. (2013) PloS one 8, e55174. PMID: 23468844 2. Tsai, VW. et al. (2014) PloS one 9, e100370. PMID: 24971956 3. Mullican, SE. et al. (2017) Nature medicine 23, 1150-1157. PMID: 28846097 4. Emmerson, PJ. et al. (2017) Nature medicine 23, 1215-1219. PMID: 28846098 5. Yang, L. et al. (2017) Nature medicine 23, 1158-1166. PMID: 28846099 6. Hsu, JY. et al. (2017) Nature 550, 255-259. PMID: 28953886 7. Xiong, Y. et al. (2017) Science translational medicine 9. PMID: 29046435 8. Patel, S. et al. (2019) Cell metabolism 29, 707-718.e8. PMID: 30639358 9. Coll, AP. et al. (2020) Nature 578, 444-448. PMID: 31875646 10. Klein, AB. et al. (2021) Nature communications 12, 1041. PMID: 33589633
注意事項	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (HyHEL-10) (HV080407) Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)