Anti-Tityus serrulatus Tityustoxin VII Reference Antibody (Serrumab, RUO) (HP769016)

Name: Anti-Tityus serrulatus Tityustoxin VII Reference Antibody (Serrumab, RUO)
Brand: abinScience
SKU: HP769016
Price: 326 USD
Availability: InStock

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Vista general

Número de catálogo	HP769016
Descripción	Serrumab (HP769016) is a research-grade recombinant antibody targeting Tityustoxin VIIToxin VIITs7. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactividad de especies	Tityus serrulatus (Brazilian scorpion)
Aplicaciones	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG1, kappa
Sistema de expresión	Mammalian cells
Objetivo	Tityustoxin VIIToxin VIITs7
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% purity as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P15226
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo	Beta-mammal/insect toxin Ts1 (Tityustoxin VIIToxin VIITs7) is a ~9 kDa protein. Voltage-gated sodium channels (Nav) gating-modifier. Acts both as alpha- and beta-toxin, since it affects not only activation but also inactivation of Nav channels (Probable). Binds to Nav domain DII and impairs the four Nav channel voltage sensors movements. Depending on Nav channel subtypes tested, can also bind Nav domains DIII (low affinity) and DIV (very low affinity). Acts on almost all the Nav channels tested (mammalian Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.4/SCN4A, Nav1.5/SCN5A, Nav1.6/SCN8A, Nav1.9/SCN11A, and insect DmNav1). 1. Peigneur, S. et al. (2015) Neuropharmacology 95, 269-77. PMID: 25862296 2. Campos, FV. et al. (2007) The Journal of general physiology 130, 257-68. PMID: 17698594 3. Bosmans, F. et al. (2008) Nature 456, 202-8. PMID: 19005548 4. Martin-Eauclaire, MF. et al. (2015) The Journal of general physiology 145, 155-62. PMID: 25624450 5. Bosmans, F. et al. (2011) The Journal of general physiology 138, 59-72. PMID: 21670206 6. Dang, B. et al. (2014) Angewandte Chemie (International ed. in English) 53, 8970-4. PMID: 24989851
Nota	For research use only. Not suitable for clinical or therapeutic use.

Imágenes

SDS-PAGE

SDS-PAGE for Research Grade Serrumab.

Referencias

Datasheet

Anti-Tityus serrulatus Tityustoxin VII Reference Antibody (Serrumab, RUO).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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C₁ (Stock Conc.)

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Working Solution

C₂ (Working Conc.)

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