InVivoMAb Anti-Brazilian scorpion Tityustoxin VII/Toxin VII/Ts7 Antibody (Iv0135) (ZP769010)

Name: InVivoMAb Anti-Brazilian scorpion Tityustoxin VII/Toxin VII/Ts7 Antibody (Iv0135)
Brand: abinScience
SKU: ZP769010
Price: 370 USD
Availability: InStock

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Overview

Catalog No.	ZP769010
Description	InVivoMAb Anti-Brazilian scorpion Tityustoxin VII/Toxin VII/Ts7 Antibody (Iv0135) [Iv0135] (ZP769010) is a human monoclonal antibody detecting Beta-mammal/insect toxin Ts1 in ELISA, Neutralization.
Species reactivity	Tityus serrulatus (Brazilian scorpion)
Applications	ELISA, Neutralization
Host species	Human
Isotype	IgG1, kappa
Clone ID	Iv0135
Clonality	Monoclonal
Target	Beta-mammal/insect toxin Ts1, Beta-like toxin Ts1, PT-Mice-Ins-beta NaTx6.1, Tityustoxin VII, Toxin VII, Ts VII, Ts7, TsTX-VII, Toxin II-11, Toxin III-10, Toxin T2-IV, Toxin gamma, T-gamma, TiTx gamma, Toxin-g, TsTX-I
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Associated products	pH 7.4 Dilution Buffer
Purification	Protein A/G purified from cell culture supernatant.
Accession	P15226
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Beta-mammal/insect toxin Ts1 (Tityustoxin VII/Toxin VII) is a ~9 kDa protein. Voltage-gated sodium channels (Nav) gating-modifier. Acts both as alpha- and beta-toxin, since it affects not only activation but also inactivation of Nav channels (Probable). Binds to Nav domain DII and impairs the four Nav channel voltage sensors movements. Depending on Nav channel subtypes tested, can also bind Nav domains DIII (low affinity) and DIV (very low affinity). Acts on almost all the Nav channels tested (mammalian Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.4/SCN4A, Nav1.5/SCN5A, Nav1.6/SCN8A, Nav1.9/SCN11A, and insect DmNav1). 1. Peigneur, S. et al. (2015) Neuropharmacology 95, 269-77. PMID: 25862296 2. Campos, FV. et al. (2007) The Journal of general physiology 130, 257-68. PMID: 17698594 3. Bosmans, F. et al. (2008) Nature 456, 202-8. PMID: 19005548 4. Martin-Eauclaire, MF. et al. (2015) The Journal of general physiology 145, 155-62. PMID: 25624450 5. Bosmans, F. et al. (2011) The Journal of general physiology 138, 59-72. PMID: 21670206 6. Dang, B. et al. (2014) Angewandte Chemie (International ed. in English) 53, 8970-4. PMID: 24989851
Note	For research use only. Not suitable for clinical or therapeutic use.

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InVivoMAb Anti-Brazilian scorpion Tityustoxin VII/Toxin VII/Ts7 Antibody (Iv0135).pdf

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InVivoMAb Anti-Brazilian scorpion Tityustoxin VII/Toxin VII/Ts7 Antibody (Iv0135) (ZP769010)

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