ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species
Tityus serrulatus (Brazilian scorpion)
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Beta-mammal/insect toxin Ts1 is a ~9 kDa protein. Voltage-gated sodium channels (Nav) gating-modifier. Acts both as alpha- and beta-toxin, since it affects not only activation but also inactivation of Nav channels (Probable). Binds to Nav domain DII and impairs the four Nav channel voltage sensors movements. Depending on Nav channel subtypes tested, can also bind Nav domains DIII (low affinity) and DIV (very low affinity). Acts on almost all the Nav channels tested (mammalian Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.4/SCN4A, Nav1.5/SCN5A, Nav1.6/SCN8A, Nav1.9/SCN11A, and insect DmNav1).
1. Peigneur, S. et al. (2015) Neuropharmacology 95, 269-77. PMID: 25862296
2. Campos, FV. et al. (2007) The Journal of general physiology 130, 257-68. PMID: 17698594
3. Bosmans, F. et al. (2008) Nature 456, 202-8. PMID: 19005548
4. Martin-Eauclaire, MF. et al. (2015) The Journal of general physiology 145, 155-62. PMID: 25624450
5. Bosmans, F. et al. (2011) The Journal of general physiology 138, 59-72. PMID: 21670206
6. Dang, B. et al. (2014) Angewandte Chemie (International ed. in English) 53, 8970-4. PMID: 24989851
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