Anti-Tityus serrulatus Tityustoxin VII Reference Antibody (Serrumab, RUO) (HP769016)

Name: Anti-Tityus serrulatus Tityustoxin VII Reference Antibody (Serrumab, RUO)
Brand: abinScience
SKU: HP769016
Price: 326 USD
Availability: InStock

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Aperçu

Numéro de catalogue	HP769016
Description	Serrumab (HP769016) is a research-grade recombinant antibody targeting Tityustoxin VIIToxin VIITs7. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactivité des espèces	Tityus serrulatus (Brazilian scorpion)
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG1, kappa
Système d'expression	Mammalian cells
Cible	Tityustoxin VIIToxin VIITs7
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P15226
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte	Beta-mammal/insect toxin Ts1 (Tityustoxin VIIToxin VIITs7) is a ~9 kDa protein. Voltage-gated sodium channels (Nav) gating-modifier. Acts both as alpha- and beta-toxin, since it affects not only activation but also inactivation of Nav channels (Probable). Binds to Nav domain DII and impairs the four Nav channel voltage sensors movements. Depending on Nav channel subtypes tested, can also bind Nav domains DIII (low affinity) and DIV (very low affinity). Acts on almost all the Nav channels tested (mammalian Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.4/SCN4A, Nav1.5/SCN5A, Nav1.6/SCN8A, Nav1.9/SCN11A, and insect DmNav1). 1. Peigneur, S. et al. (2015) Neuropharmacology 95, 269-77. PMID: 25862296 2. Campos, FV. et al. (2007) The Journal of general physiology 130, 257-68. PMID: 17698594 3. Bosmans, F. et al. (2008) Nature 456, 202-8. PMID: 19005548 4. Martin-Eauclaire, MF. et al. (2015) The Journal of general physiology 145, 155-62. PMID: 25624450 5. Bosmans, F. et al. (2011) The Journal of general physiology 138, 59-72. PMID: 21670206 6. Dang, B. et al. (2014) Angewandte Chemie (International ed. in English) 53, 8970-4. PMID: 24989851
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Serrumab.

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Anti-Tityus serrulatus Tityustoxin VII Reference Antibody (Serrumab, RUO).pdf

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