Anti-Tityus serrulatus Tityustoxin VII Reference Antibody (Serrumab, RUO) (HP769016)

Name: Anti-Tityus serrulatus Tityustoxin VII Reference Antibody (Serrumab, RUO)
Brand: abinScience
SKU: HP769016
Price: 326 USD
Availability: InStock

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Обзор

Каталожный номер	HP769016
Описание	Serrumab (HP769016) is a research-grade recombinant antibody targeting Tityustoxin VIIToxin VIITs7. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Реактивность видов	Tityus serrulatus (Brazilian scorpion)
Применения	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG1, kappa
Система экспрессии	Mammalian cells
Цель	Tityustoxin VIIToxin VIITs7
Уровень эндотоксинов	< 10 EU/mg
Чистота	>95% purity as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P15226
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон	Beta-mammal/insect toxin Ts1 (Tityustoxin VIIToxin VIITs7) is a ~9 kDa protein. Voltage-gated sodium channels (Nav) gating-modifier. Acts both as alpha- and beta-toxin, since it affects not only activation but also inactivation of Nav channels (Probable). Binds to Nav domain DII and impairs the four Nav channel voltage sensors movements. Depending on Nav channel subtypes tested, can also bind Nav domains DIII (low affinity) and DIV (very low affinity). Acts on almost all the Nav channels tested (mammalian Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.4/SCN4A, Nav1.5/SCN5A, Nav1.6/SCN8A, Nav1.9/SCN11A, and insect DmNav1). 1. Peigneur, S. et al. (2015) Neuropharmacology 95, 269-77. PMID: 25862296 2. Campos, FV. et al. (2007) The Journal of general physiology 130, 257-68. PMID: 17698594 3. Bosmans, F. et al. (2008) Nature 456, 202-8. PMID: 19005548 4. Martin-Eauclaire, MF. et al. (2015) The Journal of general physiology 145, 155-62. PMID: 25624450 5. Bosmans, F. et al. (2011) The Journal of general physiology 138, 59-72. PMID: 21670206 6. Dang, B. et al. (2014) Angewandte Chemie (International ed. in English) 53, 8970-4. PMID: 24989851
Примечание	For research use only. Not suitable for clinical or therapeutic use.

Изображения

SDS-PAGE

SDS-PAGE for Research Grade Serrumab.

Ссылки

Даташит

Anti-Tityus serrulatus Tityustoxin VII Reference Antibody (Serrumab, RUO).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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C₁ (Stock Conc.)

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C₂ (Working Conc.)

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