Anti-HCMV HCMV gH Reference Antibody (Sevirumab, RUO) (VK705016)

Name: Anti-HCMV HCMV gH Reference Antibody (Sevirumab, RUO)
Brand: abinScience
SKU: VK705016
Price: 176 USD
Availability: InStock

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Número de catálogo	VK705016
Descripción	Sevirumab (VK705016) is a research-grade recombinant antibody targeting Envelope glycoprotein H. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactividad de especies	Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5)
Aplicaciones	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG1, kappa
Sistema de expresión	Mammalian cells
Objetivo	Envelope glycoprotein H, gH, gH, UL75
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% purity as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P12824
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	EV27, MSL109, SDZMSL109, 138660-96-5
Fondo	Envelope glycoprotein H (gHUL75) is a ~84 kDa protein. The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis. In human cytomegalovirus, forms two distinct complexes to mediate viral entry, a trimer and a pentamer at the surface of the virion envelope. The gH-gL-gO trimer is required for infection in fibroblasts by interacting with host PDGFRA, and in glioblastoma cells by interacting with host EPHA2.
Nota	For research use only. Not suitable for clinical or therapeutic use.