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| カタログ番号 | VK705016 |
|---|---|
| 説明 |
Sevirumab (VK705016) is a research-grade recombinant antibody targeting Envelope glycoprotein H. Produced in mammalian cells with native-like glycosylation.
Highlights
|
| 種反応性 | Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5) |
| アプリケーション | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 宿主種 | Human |
| クローン性 | Monoclonal |
| アイソタイプ | IgG1, kappa |
| 発現システム | Mammalian cells |
| ターゲット | Envelope glycoprotein H, gH, gH, UL75 |
| エンドトキシンレベル | < 10 EU/mg |
| 純度 | >95% purity as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | P12824 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | EV27, MSL109, SDZMSL109, 138660-96-5 |
| 背景 | Envelope glycoprotein H (gHUL75) is a ~84 kDa protein. The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis. In human cytomegalovirus, forms two distinct complexes to mediate viral entry, a trimer and a pentamer at the surface of the virion envelope. The gH-gL-gO trimer is required for infection in fibroblasts by interacting with host PDGFRA, and in glioblastoma cells by interacting with host EPHA2. |
| 注意事項 | For research use only. Not suitable for clinical or therapeutic use. |
SEC-HPLC detection for Research Grade Sevirumab.
SDS-PAGE for Research Grade Sevirumab.
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