Anti-Human IL-3R alpha/CD123 Reference Antibody (Talacotuzumab, RUO) (HB714016)

Name: Anti-Human IL-3R alpha/CD123 Reference Antibody (Talacotuzumab, RUO)
Brand: abinScience
SKU: HB714016
Price: 176 USD
Availability: InStock

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Aperçu

Numéro de catalogue	HB714016
Description	Talacotuzumab (HB714016) is a research-grade recombinant antibody targeting CD123. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG1-kappa
Système d'expression	Mammalian cells
Applications testées	WB
Cible	IL-3R subunit alpha, IL-3 receptor subunit alpha, CD123, Interleukin-3 receptor subunit alpha, IL3R, IL-3R-alpha, IL3RA, IL-3RA
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P26951
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	CSL-362-AML, CSL362, JNJ-56022473, 1826831-79-1
Contexte	Interleukin-3 receptor subunit alpha (CD123/IL-3Rα) is a ~43 kDa protein. Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program. 1. Huang, S. et al. (1999) Stem cells (Dayton, Ohio) 17, 265-72. PMID: 10527461
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

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Bioactivity

Detects CD123/IL3RA in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Talacotuzumab.
Western blot

Western blot analysis was performed using anti-CD123/IL3RA monoclonal antibody at 1μg/ml on various samples.
Lane 1: recombinant human CD123/IL3RA (Catalog No: HB714011), 50ng
Lane 2: recombinant human CD123/IL3RA (Catalog No: HB714011), 30ng
Lane 3: recombinant human CD123/IL3RA (Catalog No: HB714011), 20ng