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| カタログ番号 | CV678016 | ||||
|---|---|---|---|---|---|
| 説明 |
Tirnovetmab (CV678016) is a research-grade recombinant antibody targeting IL-31. Produced in mammalian cells with native-like glycosylation.
Highlights
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| 種反応性 | Canine | ||||
| アプリケーション | ELISA, Bioactivity: FACS, Functional assay, Research in vivo | ||||
| 宿主種 | Canine | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2-Kappa | ||||
| 発現システム | Mammalian cells | ||||
| ターゲット | IL-31, Interleukin-31, IL31 | ||||
| エンドトキシンレベル | < 10 EU/mg | ||||
| 純度 | >95% purity as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | C7G0W1 | ||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 別名 | KIND-016, 2364504-80-1 | ||||
| 背景 | Tirnovetmab (KIND-016) is an antibody. Tirnovetmab can be used for experiment research. • The IL-4, IL-13 and IL-31 pathways in atopic dermatitis., PMID:34106037 • IL-31-dependent neurogenic inflammation restrains cutaneous type 2 immune response in allergic dermatitis., PMID:37831760 • Interleukin-31: The "itchy" cytokine in inflammation and therapy., PMID:33629401 • A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1., PMID:24373353 • Seladelpar treatment reduces IL-31 and pruritus in patients with primary biliary cholangitis., PMID:38117036 • Nemolizumab: First Approval., PMID:35834124 • Nemolizumab: An Innovative Biologic Treatment to Control Interleukin 31, a Key Mediator in Atopic Dermatitis and Prurigo Nodularis., PMID:35842249 • The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching., PMID:32673566 • Pruritus as a Distinctive Feature of Type 2 Inflammation., PMID:33807098 • Targeting Interleukin-31 in Prurigo., PMID:37888922 | ||||
| 注意事項 | For research use only. Not suitable for clinical or therapeutic use. |
SEC-HPLC detection for Research Grade Tirnovetmab.
SDS-PAGE for Research Grade Tirnovetmab
Detects Recombinant dog IL31 (CV678011) in indirect ELISAs.
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