Anti-Canine IL-31 Reference Antibody (SAA1416, RUO) (CV678026)

Name: Anti-Canine IL-31 Reference Antibody (SAA1416, RUO)
Brand: abinScience
SKU: CV678026
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	CV678026
Description	Anti-Dog IL31 Antibody (SAA1416) (CV678026) is a research-grade recombinant antibody targeting IL-31. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Canine
Applications	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Host species	Canine
Clonality	Monoclonal
Isotype	IgG2-kappa
Clone ID	SAA1416
Expression system	Mammalian cells
Nature	Recombinant
Target	IL-31, Interleukin-31, IL31
Endotoxin level	< 10 EU/mg as determined by LAL method.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	C7G0W1
Form	Liquid
Storage buffer	0.01M PBS pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	CAN34D3-65, PF-06443537, CAS: 1533403-95-0
Background	Dovanvetmab (ZTS-00521505) is an IgG1-κ antibody targeting Felcat IL31. Mainly expressed by CHO (Chinese Hamster Ovary) cells. • The IL-4, IL-13 and IL-31 pathways in atopic dermatitis., PMID:34106037 • IL-31-dependent neurogenic inflammation restrains cutaneous type 2 immune response in allergic dermatitis., PMID:37831760 • Interleukin-31: The "itchy" cytokine in inflammation and therapy., PMID:33629401 • A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1., PMID:24373353 • Seladelpar treatment reduces IL-31 and pruritus in patients with primary biliary cholangitis., PMID:38117036 • Nemolizumab: First Approval., PMID:35834124 • Nemolizumab: An Innovative Biologic Treatment to Control Interleukin 31, a Key Mediator in Atopic Dermatitis and Prurigo Nodularis., PMID:35842249 • The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching., PMID:32673566 • Pruritus as a Distinctive Feature of Type 2 Inflammation., PMID:33807098 • Targeting Interleukin-31 in Prurigo., PMID:37888922
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for Research Grade Anti-Dog IL31 Antibody (SAA1416)
Bioactivity

Detects Recombinant dog IL31 (CV678011) in indirect ELISAs.

References

Datasheet

Anti-Canine IL-31 Reference Antibody (SAA1416, RUO).pdf

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Formula

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Recombinant Proteins

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Anti-Canine IL-31 Reference Antibody (SAA1416, RUO) (CV678026)

Overview

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References

Datasheet

SDS