Anti-Human Integrin α5β1/ITGA5_ITGB1 Reference Antibody (Volociximab, RUO) (HY464016)

Name: Anti-Human Integrin α5β1/ITGA5_ITGB1 Reference Antibody (Volociximab, RUO)
Brand: abinScience
SKU: HY464016
Price: 176 USD
Availability: InStock

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Numéro de catalogue	HY464016
Description	Volociximab (HY464016) is a research-grade recombinant antibody targeting CD49. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Espèce hôte	Chimeric
Clonalité	Monoclonal
Isotype	IgG4-nd
Système d'expression	Mammalian cells
Nature	Recombinant
Cible	CD49 antigen-like family member E, Integrin alpha-F, ITGA5, VLA-5, Fibronectin receptor subunit alpha, CD49e, Integrin alpha-5, FNRA
Niveau d'endotoxines	< 10 EU/mg as determined by LAL method.
Pureté	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P08648
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	558480-40-3
Contexte	Integrin alpha-5 (CD49e/ITGA5) is a ~114 kDa protein. Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1. 1. Saegusa, J. et al. (2008) The Journal of biological chemistry 283, 26107-15. PMID: 18635536 2. Fujita, M. et al. (2015) The Journal of biological chemistry 290, 259-71. PMID: 25398877 3. Bax, DV. et al. (2003) The Journal of biological chemistry 278, 34605-16. PMID: 12807887 4. Jovanovic, J. et al. (2007) The Journal of biological chemistry 282, 6743-51. PMID: 17158881 5. Schumacher, S. et al. (2021) Science advances 7. PMID: 33962943 6. Takada, YK. et al. (2017) The Journal of biological chemistry 292, 20067-20075. PMID: 29030430 7. Takada, YK. et al. (2019) Journal of immunology (Baltimore, Md. : 1950) 203, 1383-1391. PMID: 31331973
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG4 (S228P) Recombinant Isotype Control Antibody (SAA0184) (HP298107)

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Anti-Human Integrin α5β1/ITGA5_ITGB1 Reference Antibody (Volociximab, RUO).pdf

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Anti-Human Integrin α5β1/ITGA5_ITGB1 Reference Antibody (Volociximab, RUO) (HY464016)

Aperçu

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