Zampilimab ELISA Kit (DB247018)

データシート製品共有情報コピー

概要
イメージ
参考文献
データシート
SDS

カタログ番号	DB247018
説明	Zampilimab ELISA Kit (DB247018) — Quantitative sandwich ELISA for Zampilimab. Sample: Plasma, Serum. Range: 0.31-5 μg/mL. Sensitivity: 0.156 μg/ml. Highlights ●Sandwich Format — High specificity, reliable quantification. ●High Sensitivity — Optimized for low-abundance target detection. ●Ready-to-Use — Complete kit with pre-coated plates included.
サンプルタイプ	Plasma, Serum
感度	0.156 μg/ml
レンジ	0.31-5 μg/mL
アクセッション番号	P21980
アプリケーション	ELISA
検出方法	Colorimetric
アッセイタイプ	Quantitative
回収率	80-120%
発送	2-8 ℃
安定性と保存	The stability of ELISA kit is determined by the loss rate of activity. The loss rate of this kit is less than 10% prior to the expiration date under appropriate storage condition.
仕様	Zampilimab
別名	UCB-7858, UCB7858, 2098280-42-1
背景	Protein-glutamine gamma-glutamyltransferase 2 (Zampilimab) is a ~77 kDa protein. Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively. Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis. Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54. Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses. When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds. 1. Kanchan, K. et al. (2013) The Biochemical journal 455, 261-72. PMID: 23941696 2. Jeong, EM. et al. (2020) International journal of molecular sciences 21. PMID: 31991788 3. Nemes, Z. et al. (1997) The Journal of biological chemistry 272, 20577-83. PMID: 9252372 4. Upchurch, HF. et al. (1991) Journal of cellular physiology 149, 375-82. PMID: 1683874 5. Lai, TS. et al. (2017) Amino acids 49, 501-515. PMID: 27270573 6. Hernandez-Fernaud, JR. et al. (2017) Nature communications 8, 14206. PMID: 28198360 7. Melino, G. et al. (1994) Molecular and cellular biology 14, 6584-96. PMID: 7935379 8. Hsieh, YF. et al. (2013) PloS one 8, e81516. PMID: 24349085
注意事項	For Research Use Only.