Anti-Human PD-1 & VEGFA Bispecific Reference Antibody (Tivunatamig, RUO) (HS870636)

Name: Anti-Human PD-1 & VEGFA Bispecific Reference Antibody (Tivunatamig, RUO)
Brand: abinScience
SKU: HS870636
Price: 370 USD
Availability: InStock

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Спецификация:

100ug
1mg

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Обзор

Каталожный номер	HS870636
Описание	Anti-Human PD-1 & VEGFA Bispecific Reference Antibody (Tivunatamig, RUO) (HS870636) is a human monoclonal antibody detecting PD-1 & VEGF,PD-1,VEGF.
Реактивность видов	Human
Применения	ELISA, FCM, Functional assay
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	immunoglobulin [VH-G4(CH1)(_L-kappa)-15mer-H-gamma4_L kappa]dimer
Цель	CD279, PD1, PDCD1, Programmed cell death protein 1, Protein PD-1, PD-1, L-VEGF, N-VEGF, VEGF, VEGFA, VPF, Vascular endothelial growth factor A, long form, Vascular permeability factor
Уровень эндотоксинов	< 10 EU/mg
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	Q15116 & P15692
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	CAS: 3077182-88-5
Фон	Programmed cell death protein 1 (PDL1 & VEGF) is a ~31 kDa protein. Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2. Following T-cell receptor (TCR) engagement, PDCD1 associates with TCR-CD3 in the immunological synapse and directly inhibits T-cell activation. Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta. 1. Fife, BT. et al. (2011) Annals of the New York Academy of Sciences 1217, 45-59. PMID: 21276005 2. Bardhan, K. et al. (2019) Scientific reports 9, 17252. PMID: 31754127 3. Patsoukis, N. et al. (2020) Communications biology 3, 128. PMID: 32184441 4. Xiao, X. et al. (2023) Nature communications 14, 2859. PMID: 37208329 5. Zak, KM. et al. (2015) Structure (London, England : 1993) 23, 2341-2348. PMID: 26602187
Примечание	For research use only.

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Anti-Human PD-1 & VEGFA Bispecific Reference Antibody (Tivunatamig, RUO).pdf

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