Anti-Human PD-1 & VEGFA Bispecific Reference Antibody (Ivonescimab, RUO) (HB941056)

Name: Anti-Human PD-1 & VEGFA Bispecific Reference Antibody (Ivonescimab, RUO)
Brand: abinScience
SKU: HB941056
Price: 400 USD
Availability: InStock

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References
Datasheet
SDS

Overview

Catalog No.	HB941056
Description	Ivonescimab (HB941056) is a research-grade recombinant antibody targeting CD1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Host species	Human
Clonality	Monoclonal
Isotype	IgG1-kappa-[scFv]2
Clone ID	Ivonescimab
Expression system	Mammalian cells
Nature	Recombinant
Tested applications	WB, FCM
Target	CD279, PD1, PDCD1, Programmed cell death protein 1, Protein PD-1, L-VEGF, N-VEGF, VEGF, VEGFA, VPF, Vascular endothelial growth factor A, long form, Vascular permeability factor
Endotoxin level	< 10 EU/mg as determined by LAL method.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q15116 & P15692
Form	Liquid
Storage buffer	0.01M PBS pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	TetravalentBispecific, AK112, AK-112, AK1122428381-53-5
Background	Ivonescimab (AK112) is a PD-1/VEGF Bispecific Antibody. Ivonescimab can be used for cancer research.
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

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Bioactivity

Detects VEGF165 in indirect ELISA.
Bioactivity

Detects recombinant human PD1 (Cat No.: HS870021) in indirect ELISA.
Flow CytoMetry

Flow-cytometry using FITC anti-human VEGFA&PD1 antibody. U87 cells were fixed and permeabilized, then stained with an irrelevant antibody (Blue Histogram) or an FITC anti-human VEGFA&PD1 monoclonal antibody (Catalog: HB941056, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.
Western blot

Western blot analysis was performed using anti-VEGFA/VEGF165 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human VEGFA/VEGF165 (Catalog No: HB941011)
Lane 2: negative control
Flow cytometry

Flow-cytometry using anti-human VEGFA antibody. Hela cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human VEGFA monoclonal antibody (Catalog HB941056, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a Goat Anti-Human IgG H&L Polyclonal Antibody, FITC (abinScience: HF690414) and cells analysed on a NovoCyte Flow Cytometer.
SDS-PAGE

SDS-PAGE for Research Grade Ivonescimab

References

Datasheet

Anti-Human PD-1 & VEGFA Bispecific Reference Antibody (Ivonescimab, RUO).pdf

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Formula

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Recombinant Proteins

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Assay Kits

Anti-Human PD-1 & VEGFA Bispecific Reference Antibody (Ivonescimab, RUO) (HB941056)

Overview

Images

References

Datasheet

SDS