Anti-Human PD-1 & VEGF Bispecific Recombinant Antibody (SSGJ-707) (HS870023)

Name: Anti-Human PD-1 & VEGF Bispecific Recombinant Antibody (SSGJ-707)
Brand: abinScience
SKU: HS870023
Price: 191 USD
Availability: InStock

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100ug
1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HS870023

Species reactivity

Human

Applications

ELISA, FACS, Functional assay

Host species

Human

Isotype

IgG4, kappa-Fab

Clone ID

SSGJ-707

Clonality

Monoclonal

Target

Programmed cell death protein 1, Protein PD-1, hPD-1, CD279, PDCD1, PD1, Vascular endothelial growth factor A long form, L-VEGF, Vascular permeability factor, VPF, N-VEGF, VEGFA, VEGFA, VEGF

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q15116, P15692

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Programmed cell death protein 1 (PDL1 & VEGF) is a ~31 kDa protein. Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2. Following T-cell receptor (TCR) engagement, PDCD1 associates with TCR-CD3 in the immunological synapse and directly inhibits T-cell activation. Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta.

1. Fife, BT. et al. (2011) Annals of the New York Academy of Sciences 1217, 45-59. PMID: 21276005

2. Bardhan, K. et al. (2019) Scientific reports 9, 17252. PMID: 31754127

3. Patsoukis, N. et al. (2020) Communications biology 3, 128. PMID: 32184441

4. Xiao, X. et al. (2023) Nature communications 14, 2859. PMID: 37208329

5. Zak, KM. et al. (2015) Structure (London, England : 1993) 23, 2341-2348. PMID: 26602187

Note

For research use only

Images

References

Datasheet

Anti-Human PD-1 & VEGF Bispecific Recombinant Antibody (SSGJ-707).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human PD-1 & VEGF Bispecific Recombinant Antibody (SSGJ-707) (HS870023)

Overview

Images

References

Datasheet

SDS

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